Pulmonary arterial hypertension (PH) is a progressive disease of increased resistance to flow through the lungs, leading to right ventricular (RV) failure . MRI is increasingly used to assess right ventricular (RV) function in PH. RV stroke work (SW) based on invasive pressure and volume measurements, is used to assess ventricular work. Determining RV work from MRI could enable a more complete characterization of RV and PA interactions in PH. The purpose of this study was to non-invasively estimate RV work from simultaneously acquired RV volume (VRV) and pulmonary artery flow (QPA) using a 4D flow-sensitive MRI sequence in a canine model.
Alejandro Roldán-Alzate, Scott Grogan, Heidi Kellihan, Alessandro Bellofiore, Naomi Chesler, Oliver Wieben, and Christopher Francois. "Non-invasive right ventricular efficiency using 4D flow MRI" Faculty Publications (2015). doi:10.1186/1532-429X-17-S1-Q58