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Date of Award
Thesis - Campus Access Only
Master of Science (MS)
Biology; Molecular biology
Radiation is present all around us, whether it is natural or man-made. Depending upon the type, intensity and duration, radiation exposure can pose a serious threat to an individual's survival. A number of research studies have been conducted to investigate various synthetic and natural compounds for their radioprotective properties. Curcumin, a natural polyphenol, has been extensively studied for its free radical-scavenging properties. In this study, we evaluated the radioprotective effects of 10 µM curcumin on 2 Gy gamma-irradiated Chinese hamster ovary cells. Survival curves were used to analyze CHO cell survival at different doses of gamma radiation, with and without curcumin pretreatment. The resulting data indicated a higher surviving fraction for curcumin-pretreated cells compared to untreated cells. Cell survival was estimated using a colony-forming assay. The assay showed that 10 µM curcumin pretreatment resulted in a greater number of colonies formed by CHO cells after 2 Gy irradiation. Furthermore, it was also observed that postirradiation incubation of CHO cells irradiated in the presence of 10 µM curcumin at 37oC resulted in decreased cell survival.
Kukreja, Monica, "Radioprotective Effects Of 10 µM Curcumin On 2 Gy Gamma- Irradiated CHO Cells" (2012). Master's Theses. Paper 4142.