Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.
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Q L. Ch'ng. "Commentary: Selecting synaptic partners: GRASPing the role of UNC- 6/netrin" BMC Biology (2011): 43-45. DOI: 10.1186/1741-7007-9-43