Publication Date

Spring 5-26-2021

Degree Type

Master's Project

Degree Name

Master of Science in Computer Science (MSCS)

Department

Computer Science

First Advisor

Leonard Wesley

Second Advisor

Wendy Lee

Third Advisor

Alyson Rosen

Keywords

Financial Capacity, Bionformatics, Predicting Cognitive Decline

Abstract

Financial Capacity (FC) is the ability to manage one’s financial affairs, which is essential for autonomy and independence particularly for aging adults. Since dementia develops gradually, it is often difficult to detect the early signs that this cognitive dysfunction is developing This project aims to use Neurite orientation dispersion and density imaging (NODDI) to identify the white matter tracts that are associated with FC. Diffusion Tensor Images (DTI) and T1 Magnetic Resonance Images (MRI) of 18 Alzheimer’s Disease (AD) subjects, 47 Mild Cognitive Impaired (MCI) subjects, and 193 healthy control (CN) are compared to neuropsychological tests. Orientation Dispersion Index (ODI) values are derived using NODDI analysis of the DTI and MRI. This study found that the ODI values in the cingulum have the highest association with FC. In conclusion, our study suggested that the degradation of white matter and episodic memory dysfunction were most strongly associated with reduced FC.

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