Master of Science in Computer Science (MSCS)
Financial Capacity, Bionformatics, Predicting Cognitive Decline
Financial Capacity (FC) is the ability to manage one’s financial affairs, which is essential for autonomy and independence particularly for aging adults. Since dementia develops gradually, it is often difficult to detect the early signs that this cognitive dysfunction is developing This project aims to use Neurite orientation dispersion and density imaging (NODDI) to identify the white matter tracts that are associated with FC. Diffusion Tensor Images (DTI) and T1 Magnetic Resonance Images (MRI) of 18 Alzheimer’s Disease (AD) subjects, 47 Mild Cognitive Impaired (MCI) subjects, and 193 healthy control (CN) are compared to neuropsychological tests. Orientation Dispersion Index (ODI) values are derived using NODDI analysis of the DTI and MRI. This study found that the ODI values in the cingulum have the highest association with FC. In conclusion, our study suggested that the degradation of white matter and episodic memory dysfunction were most strongly associated with reduced FC.
Tai, Lok Yi, "Prediction of Financial Capacity using Diffusion Compartment Imaging" (2021). Master's Projects. 1018.