Assessing Neural Synchrony in the Cochlear Nerve to Electrical Stimulation in Children With Auditory Neuropathy Spectrum Disorder
Publication Date
7-22-2024
Document Type
Article
Publication Title
Ear and Hearing
DOI
10.1097/AUD.0000000000001567
Abstract
Objectives:
This study reported phase locking values (PLVs) that quantified the trial-to-trial phase coherence of electrically evoked compound action potentials in children with auditory neuropathy spectrum disorders (ANSD) and children with Gap Junction Beta 2 (GJB2) mutations, a patient population without noticeable cochlear nerve damage.
Design:
PLVs were measured at three electrode locations in 11 children with ANSD and 11 children with GJB2 mutations. Smaller PLVs indicated poorer neural synchrony. A linear mixed-effects model was used to compare PLVs measured at different electrode locations between participant groups.
Results:
After controlling for the stimulation level effect, children with ANSD had smaller PLVs than children with GJB2 mutations at all three electrode locations.
Conclusions:
Cochlear-implanted children with ANSD show poorer peripheral neural synchrony than children with GJB2 mutations.
Funding Number
1R01 DC017846, R21 DC019458
Funding Sponsor
National Institutes of Health
Keywords
Auditory neuropathy spectrum disorder, Cochlear nerve, Electrical stimulation, Neural synchrony
Department
Audiology
Recommended Citation
Shuman He, Xiuhua Chao, Yi Yuan, Jeffrey Skidmore, and Kristin M. Uhler. "Assessing Neural Synchrony in the Cochlear Nerve to Electrical Stimulation in Children With Auditory Neuropathy Spectrum Disorder" Ear and Hearing (2024). https://doi.org/10.1097/AUD.0000000000001567
