Document Type
Article
Publication Date
1-1-2007
Publication Title
Neural Development
Volume
2
Issue Number
1
First Page
18
Last Page
24
DOI
10.1186/1749-8104-2-24
Disciplines
Biology
Abstract
The left and right AWC olfactory neurons in Caenorhabditis elegans differ in their functions and in their expression of chemosensory receptor genes; in each animal, one AWC randomly takes on one identity, designated AWCOFF, and the contralateral AWC becomes AWCON. Signaling between AWC neurons induces left-right asymmetry through a gap junction network and a claudin-related protein, which inhibit a calcium-regulated MAP kinase pathway in the neuron that becomes AWCON. Results We show here that the asymmetry gene olrn-1 acts downstream of the gap junction and claudin genes to inhibit the calcium-MAP kinase pathway in AWCON. OLRN-1, a protein with potential membrane-association domains, is related to the Drosophila Raw protein, a negative regulator of JNK mitogen-activated protein (MAP) kinase signaling. olrn-1 opposes the action of two voltage-activated calcium channel homologs, unc-2 (CaV2) and egl-19 (CaV1), which act together to stimulate the calcium/calmodulin-dependent kinase CaMKII and the MAP kinase pathway. Calcium channel activity is essential in AWCOFF, and the two AWC neurons coordinate left-right asymmetry using signals from the calcium channels and signals from olrn-1. Conclusion olrn-1 and voltage-activated calcium channels are mediators and targets of AWC signaling that act at the transition between a multicellular signaling network and cell-autonomous execution of the decision. We suggest that the asymmetry decision in AWC results from the intercellular coupling of voltage-regulated channels, whose cross-regulation generates distinct calcium signals in the left and right AWC neurons. The interpretation of these signals by the kinase cascade initiates the sustained difference between the two cells."
Recommended Citation
S L. Bauer Haung, Y Saheki, Miri VanHoven, I Torayama, T Ishihara, I Katsura, A Van der Linden, P Sengupta, and C I. Bargmann. "Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans" Neural Development (2007): 18-24. https://doi.org/10.1186/1749-8104-2-24
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This work is licensed under a Creative Commons Attribution 2.0 License.
Comments
This article is licensed under a Creative Commons Attribution 2.0 License. The publisher's version of the article may be found online at: http://dx.doi.org/10.1186/1749-8104-2-24.