Publication Date
Spring 2022
Degree Type
Master's Project
Degree Name
Master of Science in Bioinformatics (MSBI)
Department
Computer Science
First Advisor
Wendy Lee
Keywords
RNA-Seq, Biofilm, Candida Coculture, Antibiotic Resistance
Abstract
ABSTRACT Candida albicans and Candida glabrata are common fungal species that can change from commensal to pathogen due to their ability to form robust biofilms. Candida species are the leading cause of life-threatening conditions like Candidemia, and the existing treatments for biofilm-related infections are suboptimal. Research shows that the relative abundance of the two Candida species promotes biofilm formation, enhances pathogenicity, and increases antibiotic resistance. Thus, focusing on the importance of coculture, this paper utilizes RNA sequencing to investigate the gene expression leading to biofilm development in coculture through a time-series study.
Recommended Citation
Kool, Diksha, "UNDERSTANDING HOW THE RELATIVE ABUNDANCE OF CANDIDA SPECIES IMPACTS TRANSCRIPTIONAL REGULATION IN COCULTURE BIOFILMS" (2022). Master's Projects. 1093.
DOI: https://doi.org/10.31979/etd.ezqd-p2np
https://scholarworks.sjsu.edu/etd_projects/1093
