BCl3-Activated Synthesis of COO-BODIPY Laser Dyes: General Scope and High Yields under Mild Conditions
Journal of Organic Chemistry
A general and straightforward method for the synthesis of COO-BODIPYs from F-BODIPYs and carboxylic acids is established. The method is based on the use of boron trichloride to activate the involved substitution of fluorine, which leads to high yields through rapid reactions under soft conditions. This mild method opens the way to unprecedented laser dyes with outstanding efficiencies and photostabilities, which are difficult to obtain by the current methods.
National Institutes of Health
César Ray, Christopher Schad, Florencio Moreno, Beatriz L. Maroto, Jorge Bañuelos, Teresa Arbeloa, Inmaculada Garciá-Moreno, Cassie Villafuerte, Gilles Muller, and Santiago De La Moya. "BCl3-Activated Synthesis of COO-BODIPY Laser Dyes: General Scope and High Yields under Mild Conditions" Journal of Organic Chemistry (2020): 4594-4601. https://doi.org/10.1021/acs.joc.9b03059