Understanding How the Relative Abundance of Candida Species Impacts Transcriptional Regulation in Co-culture Biofilms
Publication Date
1-1-2021
Document Type
Conference Proceeding
Publication Title
Proceedings - 2021 International Conference on Computational Science and Computational Intelligence, CSCI 2021
DOI
10.1109/CSCI54926.2021.00134
First Page
376
Last Page
378
Abstract
Candida albicans and Candida glabrata are common fungal species that can change from commensal to pathogen due to their ability to form robust biofilms. Candida species are the leading cause of life-threatening conditions like Candidemia, and the existing treatments for biofilm-related infections are suboptimal. Research shows that the relative abundance of the two Candida species promotes biofilm formation, enhances pathogenicity, and increases antibiotic resistance. Thus, focusing on the importance of co-culture, this paper utilizes RNA sequencing to investigate the gene expression leading to biofilm development in co-culture through a time-series study.
Keywords
Antibiotic Resistance, Biofilm, Candida Co-culture, Candidemia, RNA-Seq
Department
Chemical and Materials Engineering; Computer Science
Recommended Citation
Diksha Kool, Katy Kao, and Wendy Lee. "Understanding How the Relative Abundance of Candida Species Impacts Transcriptional Regulation in Co-culture Biofilms" Proceedings - 2021 International Conference on Computational Science and Computational Intelligence, CSCI 2021 (2021): 376-378. https://doi.org/10.1109/CSCI54926.2021.00134
