Document Type
Article
Publication Date
March 2017
Publication Title
JCI Insight
Volume
2
Issue Number
6
DOI
10.1172/jci.insight.90233
ISSN
2379-3708
Disciplines
Biology | Microbiology | Neuroscience and Neurobiology
Abstract
Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to target sites for local immunity. We used multiparameter flow cytometry to define PB trafficking programs (TPs, combinations of adhesion molecules and chemoattractant receptors) and their imprinting in patients in response to localized infection or immune insults. TPs enriched after infection or autoimmune inflammation of mucosae correlate with sites of immune response or symptoms, with different TPs imprinted during small intestinal, colon, throat, and upper respiratory immune challenge. PBs induced after intramuscular or intradermal influenza vaccination, including flu-specific antibody–secreting cells, display TPs characterized by the lack of mucosal homing receptors. PBs of healthy donors display diverse mucosa-associated TPs, consistent with homeostatic immune activity. Identification of TP signatures of PBs may facilitate noninvasive monitoring of organ-specific immune responses.
Recommended Citation
Yekyung Seong, Nicole Lazarus, Lusijah Sutherland, Aida Habtezion, Tzvia Abramson, Xiao-Song He, Harry Greenberg, and Eugene Butcher. "Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge" JCI Insight (2017). https://doi.org/10.1172/jci.insight.90233
Comments
This article originally appeared in JCI Insight, volume 2, issue 6, 2017, and published by the American Society for Clinical Investigation (ASCI). Permission to share the article on here was granted by the publisher. The article can also be found online at this link.