Document Type

Article

Publication Date

May 2012

Abstract

The adaptive landscape for an industrially relevant phenotype is determined by the effects of the genetic determinants on the fitness of the microbial system. Identifying the underlying adaptive landscape for a particular phenotype of interest will greatly enhance our abilities to engineer more robust microbial strains. Visualizing evolution in real-time (VERT) is a recently developed method based on in vitro adaptive evolution that facilitates the identification of fitter mutants throughout the course of evolution. Combined with high-throughput genomic tools, VERT can greatly enhance the mapping of adaptive landscapes of industrially relevant phenotypes in microbial systems, thereby expanding our knowledge on the parameters that can be used for strain engineering.

Comments

SJSU users: Use the following link to login and access the article via SJSU databases.This article was published in Frontiers in Microbiology, volume 3, 2012, and can also be found online here.Copyright: © 2012 Reyes, Winkler and Kao

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