Date Updated

4-12-2024

Department

Chemistry

Academic Rank

Professor Emeritus

Year Retired from SJSU

2022

Facebook or Website URL

orcid logo https://orcid.org/0000-0003-1915-5945

National Library of Medicine; Daryl Eggers's Bibliography

https://www.ncbi.nlm.nih.gov/myncbi/1hsCju9W96lkc/bibliography/public/

Educational Background

University of California, San Francisco, Pharmacology, PhD 1997

University of California, Berkeley, Chemical Engineering, MS 1987

Rose-Hulman Institute of Technology, Chemical Engineering, BS 1981

Dissertation Title

Characterization of Nascent Polypeptides and their Molecular Chaperones in Mammalian Cells

Teaching Experience

San Jose State University, Chemistry, Professor, 2013-2023

San Jose State University, Chemistry, Associate Professor, 2008 - 2013

San Jose State University, Chemistry, Assistant Professor, 2002- 2008

University of California Los Angeles, Postdoctoral Fellow, 1997-02

University of California, Los Angeles, Summer Lecturer, Biochemistry, 1998, 1999

Research interests include Protein folding, especially the effects of molecular crowding and molecular confinement; Hydration effects on biological phenomena, including protein folding & aggregation ;Sol-gel glass applications and biosilica formation; Biochemistry and Biophysical Chemistry.

Administrative and Professional Experience

Chemist II, Syntex Research Palo Alto, CA 1987-1990

Associate Engineer, M,W, Kellogg Company, Houston, TX 1981-1984

Service

CSUPERB, the CSU Program for Education and Research in Biotechnology:

  • Faculty Consensus Group (2007-2023);
  • Strategic Planning Council (2009-19);
  • Former Chair of CSUPERB’s Biofuels Taskforce;
  • Founder and former Chair of CSU Bioengineering Network.

SJSU University Library Board (2012-15); Chair 2013/14 and 2014/15

Committee on Inclusion and Diversity, Biophysical Society (2017-2023); Vice-Chair (2018-2022)

Grant Review Panels:

  • NIH – NIGMS/SCORE (2005, 2016); S10 Instrumentation (2009, 2010) NSF – CHE/MCB (2009); CHE/MRI (2010, 2015, 2018) CSUPERB – (2006-08, 2010-15, 2017, 2019, 2020-22)

Manuscript Reviewer:

  • Accounts of Chemical Research; Angewandte Chemie; Biochemistry; Biomaterials; Biophysical Chemistry; Biophysical Journal; Chemical Communications; Chemistry of Materials; Journal of Physical Chemistry; PNAS; Protein Science.

Selected Publications

Search Scholarworks: https://scholarworks.sjsu.edu/ by author name for all works

Harmon, C., Bui, A., Espejo, J.M., Gancayco, M., Le, J.M., Rangel, J., and D.K. Eggers: Solvation free energy in governing equations for DNA hybridization, protein–ligand binding, and protein folding. bioRxiv (2024). DOI: 10.1101/2024.03.15.585270

Eggers, D.K., Le, J.M., Nham, N.T., Pham, D.N., and B.M. Castellano: Dual effect of secondary solutes on binding equilibria: Contributions from solute–reactant interactions and solute–water interactions. ACS Omega 9:3017-3027 (2024). DOI: 10.1021/acsomega.3c09329 (open access).
https://scholarworks.sjsu.edu/faculty_rsca/4037/

Eggers, D.K., Brewer, A., Cacatian, K.J., Camat, L.A., Castagnoli, D., Chuang, N., Chung, L.N., Do, T., Huynh, E., Jenpichitkulchai, T., Kaur, A., Le, F., Ong, R., Pham, D., and K. Shao: Model binding experiments with cucurbit[7]uril and p-sulfonatocalix[4]arene support use of explicit solvation term in governing equation for binding equilibria. Supramol. Chem. 34:94-104 (2023). DOI: 10.1080/10610278.2023.2254442 (open access)
https://scholarworks.sjsu.edu/faculty_rsca/4000/

Lauren Wells, Cory Vierra, Janee’ Hardman, Yanxiao Han, et al.. "Sulfoglycodendrimer Therapeutics for HIV-1 and SARS-CoV-2" Advanced Therapeutics Vol. 4 Iss. 4 (2021) https://scholarworks.sjsu.edu/faculty_rsca/2533/

Daryl K. Eggers, Sherry Fu, Dominic V. Ngo, Elizabeth H. Vuong, and T. Brotin. "Thermodynamic Contribution of Water in Cryptophane Host-Guest Binding Reaction" Journal of Physical Chemistry B Vol. 124 Iss. 30 (2020) p. 6585 - 6591 DOI: 10.1021/acs.jpcb.0c05354 https://scholarworks.sjsu.edu/faculty_rsca/1237/

Cory Vierra, Daryl K. Eggers, Celia C. Labranche and Katherine D. McReynolds. "An Efficient Microwave-Mediated Synthesis of Hexavalent Sialic Acid Sulfoglycodendrimers as Potential Anti-HIV Agents" ACS Applied Polymer Materials Vol. 2 Iss. 11 (2020) p. 4345 - 4351 https://scholarworks.sjsu.edu/faculty_rsca/1224/

Alan Tran, Angelina Tang, Colleen T O’Loughlin, Anthony Balistreri, et al.. "C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor" eLife Vol. 6 (2017) ISSN: 2050-084X https://scholarworks.sjsu.edu/chem_pub/47/

Daryl K. Eggers. "Effect of Co-Solutes on Model Reaction Equilibria: Might Changes in the Free Energy of Bulk Water be the Underlying Cause?" Biophysical Journal (2016) https://doi.org/10.1016/j.bpj.2015.11.336

Daryl K. Eggers, Jennifer M. Le, Duc N. Pham, Nhi T. Nham, et al.. "Desolvation Energy: A Rationale for Changes in Binding Affinity as Measured by ITC" Biophysical Journal(2015) https://doi.org/10.1016/j.bpj.2014.11.641

Castellano, B.M., and D.K. Eggers: Experimental support for a desolvation energy term in governing equations for binding equilibria. J. Phys. Chem. B 117:8180-8188 (2013). DOI: 10.1021/jp402632a

Daryl K. Eggers, P. J Calabretta, M. C Chancellor, C. Torres, et al.. "Silica as a Matrix for Encapsulating Proteins:Surface Effects on Protein Structure Assessed by Circular Dichroism Spectroscopy" Journal of Functional Biomaterials Vol. 3 Iss. 3 (2012)
https://scholarworks.sjsu.edu/chem_pub/1/

Payumo, A.Y., Huijon, R.M., Mansfield, D.D., Belk, L.M., Bui, A.K., Knight, A.E., and D.K. Eggers: Changes in apparent molar water volume and DKP solubility yield insights on the Hofmeister effect. J. Phys. Chem. B 115:14784-14788 (2011). DOI: 10.1021/jp206486z https://scholarworks.sjsu.edu/chem_pub/2/

Eggers, D.K.: A bulk water-dependent desolvation energy model for analyzing the effects of secondary solutes on biological equilibria. Biochemistry 50:2004-2012 (2011). DOI: 10.1021/bi1017717 https://scholarworks.sjsu.edu/chem_pub/8/

Daryl K. Eggers, B. Menaa, M. Herrero, V. Rives, et al.. "Favourable Influence of Hydrophobic Surfaces on Protein Structure in Porous Organically-Modified Silica Glasses" Biomaterials Vol. 29 Iss. 18 (2008)
https://scholarworks.sjsu.edu/chem_pub/6/

Daryl K. Eggers, B, Menaa, C. Torres, M. Herrero, et al.. "Protein Adsorption Onto Organically-Modified Silica Glass Leads to a Different Structure than Sol-Gel Encapsulation" Biophysical Journal Vol. 95 Iss. 8 (2008)
https://scholarworks.sjsu.edu/chem_pub/4/

Daryl K. Eggers and V. A Rocha. "Hydrophobic, Organically-Modified Silica Gels Enhance the Structure of Encapsulated Apomyoglobin" Chemical Communications Vol. 2007 Iss. 12 (2007)
https://scholarworks.sjsu.edu/chem_pub/7/

Daryl K. Eggers, J. A Rodriguez, B. F Shaw, A. Durazo, et al.. "Destabilization of Apoprotein Is Insufficient to Explain Cu,Zn-Superoxide Dismutase-Linked ALS Pathogenesis" Proceeding of the National Academy of Sciences Vol. 102 (2005) https://www.pnas.org/doi/full/10.1073/pnas.0502515102

Daryl K. Eggers, J. A Rodriguez, J. S Valentine, J. A Roe, et al.. "Familial ALS-Associated Mutations Decrease the Thermal Stability of Distinctly Metallated Species of Human Copper/Zinc Superoxide Dismutase" The Journal of Biological Chemistry Vol. 277 (2002)
https://scholarworks.sjsu.edu/chem_pub/3/

Eggers, D.K., and J.S. Valentine: Crowding and hydration effects on protein conformation: a study with sol-gel encapsulated proteins. J. Mol. Biol. 314:911-922(2001). DOI: 10.1006/jmbi.2001.5166

Daryl K. Eggers and J. S Valentine. "Molecular Confinement Influences Protein Structure and Enhances Thermal Protein Stability" Protein Science Vol. 10 (2001)
https://doi.org/10.1110/ps.36201

Hongbin Liu, Haining Zhu, Daryl K. Eggers, Aram M. Nersissian, et al.. "Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant" Biochemistry Vol. 39 Iss. 28 (2000) p. 8125 - 8132 ISSN: 0006-2960
https://doi.org/10.1021/bi000846f

Eggers, D.K., W.J. Welch, and W.J. Hansen: Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells. Mol. Biol. Cell 8:1559-1573 (1997). DOI: 10.1091/mbc.8.8.1559 https://scholarworks.sjsu.edu/chem_pub/5/

Eggers, D.K., H.W. Blanch, and J.M. Prausnitz: Extractive catalysis: solvent effects on equilibria of enzymatic reactions in two-phase systems. Enzyme Microb. Technol. 11:84-89 (1989). https://doi.org/10.1016/0141-0229(89)90065-3

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Eggers, Daryl K.

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