Date Updated




Academic Rank

Professor Emeritus

Year Retired from SJSU


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National Library of Medicine; Daryl Eggers's Bibliography

Educational Background

University of California, San Francisco, Pharmacology, PhD 1997

University of California, Berkeley, Chemical Engineering, MS 1987

Rose-Hulman Institute of Technology, Chemical Engineering, BS 1981

Dissertation Title

Characterization of Nascent Polypeptides and their Molecular Chaperones in Mammalian Cells

Teaching Experience

San Jose State University, Chemistry, Professor, 2013-2023

San Jose State University, Chemistry, Associate Professor, 2008 - 2013

San Jose State University, Chemistry, Assistant Professor, 2002- 2008

University of California Los Angeles, Postdoctoral Fellow, 1997-02

University of California, Los Angeles, Summer Lecturer, Biochemistry, 1998, 1999

Research interests include Protein folding, especially the effects of molecular crowding and molecular confinement; Hydration effects on biological phenomena, including protein folding & aggregation ;Sol-gel glass applications and biosilica formation; Biochemistry and Biophysical Chemistry.

Administrative and Professional Experience

Chemist II, Syntex Research Palo Alto, CA 1987-1990

Associate Engineer, M,W, Kellogg Company, Houston, TX 1981-1984


CSUPERB, the CSU Program for Education and Research in Biotechnology:

  • Faculty Consensus Group (2007-2023);
  • Strategic Planning Council (2009-19);
  • Former Chair of CSUPERB’s Biofuels Taskforce;
  • Founder and former Chair of CSU Bioengineering Network.

SJSU University Library Board (2012-15); Chair 2013/14 and 2014/15

Committee on Inclusion and Diversity, Biophysical Society (2017-2023); Vice-Chair (2018-2022)

Grant Review Panels:

  • NIH – NIGMS/SCORE (2005, 2016); S10 Instrumentation (2009, 2010) NSF – CHE/MCB (2009); CHE/MRI (2010, 2015, 2018) CSUPERB – (2006-08, 2010-15, 2017, 2019, 2020-22)

Manuscript Reviewer:

  • Accounts of Chemical Research; Angewandte Chemie; Biochemistry; Biomaterials; Biophysical Chemistry; Biophysical Journal; Chemical Communications; Chemistry of Materials; Journal of Physical Chemistry; PNAS; Protein Science.

Selected Publications

Search Scholarworks: by author name for all works

Harmon, C., Bui, A., Espejo, J.M., Gancayco, M., Le, J.M., Rangel, J., and D.K. Eggers: Solvation free energy in governing equations for DNA hybridization, protein–ligand binding, and protein folding. bioRxiv (2024). DOI: 10.1101/2024.03.15.585270

Eggers, D.K., Le, J.M., Nham, N.T., Pham, D.N., and B.M. Castellano: Dual effect of secondary solutes on binding equilibria: Contributions from solute–reactant interactions and solute–water interactions. ACS Omega 9:3017-3027 (2024). DOI: 10.1021/acsomega.3c09329 (open access).

Eggers, D.K., Brewer, A., Cacatian, K.J., Camat, L.A., Castagnoli, D., Chuang, N., Chung, L.N., Do, T., Huynh, E., Jenpichitkulchai, T., Kaur, A., Le, F., Ong, R., Pham, D., and K. Shao: Model binding experiments with cucurbit[7]uril and p-sulfonatocalix[4]arene support use of explicit solvation term in governing equation for binding equilibria. Supramol. Chem. 34:94-104 (2023). DOI: 10.1080/10610278.2023.2254442 (open access)

Lauren Wells, Cory Vierra, Janee’ Hardman, Yanxiao Han, et al.. "Sulfoglycodendrimer Therapeutics for HIV-1 and SARS-CoV-2" Advanced Therapeutics Vol. 4 Iss. 4 (2021)

Daryl K. Eggers, Sherry Fu, Dominic V. Ngo, Elizabeth H. Vuong, and T. Brotin. "Thermodynamic Contribution of Water in Cryptophane Host-Guest Binding Reaction" Journal of Physical Chemistry B Vol. 124 Iss. 30 (2020) p. 6585 - 6591 DOI: 10.1021/acs.jpcb.0c05354

Cory Vierra, Daryl K. Eggers, Celia C. Labranche and Katherine D. McReynolds. "An Efficient Microwave-Mediated Synthesis of Hexavalent Sialic Acid Sulfoglycodendrimers as Potential Anti-HIV Agents" ACS Applied Polymer Materials Vol. 2 Iss. 11 (2020) p. 4345 - 4351

Alan Tran, Angelina Tang, Colleen T O’Loughlin, Anthony Balistreri, et al.. "C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor" eLife Vol. 6 (2017) ISSN: 2050-084X

Daryl K. Eggers. "Effect of Co-Solutes on Model Reaction Equilibria: Might Changes in the Free Energy of Bulk Water be the Underlying Cause?" Biophysical Journal (2016)

Daryl K. Eggers, Jennifer M. Le, Duc N. Pham, Nhi T. Nham, et al.. "Desolvation Energy: A Rationale for Changes in Binding Affinity as Measured by ITC" Biophysical Journal(2015)

Castellano, B.M., and D.K. Eggers: Experimental support for a desolvation energy term in governing equations for binding equilibria. J. Phys. Chem. B 117:8180-8188 (2013). DOI: 10.1021/jp402632a

Daryl K. Eggers, P. J Calabretta, M. C Chancellor, C. Torres, et al.. "Silica as a Matrix for Encapsulating Proteins:Surface Effects on Protein Structure Assessed by Circular Dichroism Spectroscopy" Journal of Functional Biomaterials Vol. 3 Iss. 3 (2012)

Payumo, A.Y., Huijon, R.M., Mansfield, D.D., Belk, L.M., Bui, A.K., Knight, A.E., and D.K. Eggers: Changes in apparent molar water volume and DKP solubility yield insights on the Hofmeister effect. J. Phys. Chem. B 115:14784-14788 (2011). DOI: 10.1021/jp206486z

Eggers, D.K.: A bulk water-dependent desolvation energy model for analyzing the effects of secondary solutes on biological equilibria. Biochemistry 50:2004-2012 (2011). DOI: 10.1021/bi1017717

Daryl K. Eggers, B. Menaa, M. Herrero, V. Rives, et al.. "Favourable Influence of Hydrophobic Surfaces on Protein Structure in Porous Organically-Modified Silica Glasses" Biomaterials Vol. 29 Iss. 18 (2008)

Daryl K. Eggers, B, Menaa, C. Torres, M. Herrero, et al.. "Protein Adsorption Onto Organically-Modified Silica Glass Leads to a Different Structure than Sol-Gel Encapsulation" Biophysical Journal Vol. 95 Iss. 8 (2008)

Daryl K. Eggers and V. A Rocha. "Hydrophobic, Organically-Modified Silica Gels Enhance the Structure of Encapsulated Apomyoglobin" Chemical Communications Vol. 2007 Iss. 12 (2007)

Daryl K. Eggers, J. A Rodriguez, B. F Shaw, A. Durazo, et al.. "Destabilization of Apoprotein Is Insufficient to Explain Cu,Zn-Superoxide Dismutase-Linked ALS Pathogenesis" Proceeding of the National Academy of Sciences Vol. 102 (2005)

Daryl K. Eggers, J. A Rodriguez, J. S Valentine, J. A Roe, et al.. "Familial ALS-Associated Mutations Decrease the Thermal Stability of Distinctly Metallated Species of Human Copper/Zinc Superoxide Dismutase" The Journal of Biological Chemistry Vol. 277 (2002)

Eggers, D.K., and J.S. Valentine: Crowding and hydration effects on protein conformation: a study with sol-gel encapsulated proteins. J. Mol. Biol. 314:911-922(2001). DOI: 10.1006/jmbi.2001.5166

Daryl K. Eggers and J. S Valentine. "Molecular Confinement Influences Protein Structure and Enhances Thermal Protein Stability" Protein Science Vol. 10 (2001)

Hongbin Liu, Haining Zhu, Daryl K. Eggers, Aram M. Nersissian, et al.. "Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant" Biochemistry Vol. 39 Iss. 28 (2000) p. 8125 - 8132 ISSN: 0006-2960

Eggers, D.K., W.J. Welch, and W.J. Hansen: Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells. Mol. Biol. Cell 8:1559-1573 (1997). DOI: 10.1091/mbc.8.8.1559

Eggers, D.K., H.W. Blanch, and J.M. Prausnitz: Extractive catalysis: solvent effects on equilibria of enzymatic reactions in two-phase systems. Enzyme Microb. Technol. 11:84-89 (1989).



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Eggers, Daryl K.