Isotachophoresis-Enhanced Immunoassays: Challenges and opportunities
Publication Date
4-1-2020
Document Type
Article
Publication Title
IEEE Nanotechnology Magazine
Volume
14
Issue
2
DOI
10.1109/MNANO.2020.2966028
First Page
6
Last Page
17
Abstract
Protein detection and quantification is a crucial part of many clinical, research, and preparatory applications [1]. Protein biomarkers, such as prostate-specific antigen (PSA) [2] and carcinoembryonic antigen (CEA), are regularly detected and quantified for cancer diagnosis and treatment monitoring [3]. On the other hand, cardiac troponin 1 (CTn1) is the most important protein to quantify to detect cardiac injury and myocardial infarction [4]. The detection of protein biomarkers such as PSA, CEA, and CTn1 requires specific identification and quantification of the protein, eliminating detection techniques that enable only size-based quantification of proteins in general, such as silver staining and simple gel electrophoresis [5].
Department
Chemistry
Recommended Citation
Ruba Khnouf and Crystal Han. "Isotachophoresis-Enhanced Immunoassays: Challenges and opportunities" IEEE Nanotechnology Magazine (2020): 6-17. https://doi.org/10.1109/MNANO.2020.2966028
