Title

Isotachophoresis-Enhanced Immunoassays: Challenges and opportunities

Publication Date

4-1-2020

Document Type

Article

Department

Chemistry

Publication Title

IEEE Nanotechnology Magazine

Volume

14

Issue

2

DOI

10.1109/MNANO.2020.2966028

First Page

6

Last Page

17

Abstract

Protein detection and quantification is a crucial part of many clinical, research, and preparatory applications [1]. Protein biomarkers, such as prostate-specific antigen (PSA) [2] and carcinoembryonic antigen (CEA), are regularly detected and quantified for cancer diagnosis and treatment monitoring [3]. On the other hand, cardiac troponin 1 (CTn1) is the most important protein to quantify to detect cardiac injury and myocardial infarction [4]. The detection of protein biomarkers such as PSA, CEA, and CTn1 requires specific identification and quantification of the protein, eliminating detection techniques that enable only size-based quantification of proteins in general, such as silver staining and simple gel electrophoresis [5].

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