Diagnostic assessment in primary progressive aphasia: An illustrative case example

Publication Date

11-1-2020

Document Type

Article

Publication Title

American Journal of Speech-Language Pathology

Volume

29

Issue

4

DOI

10.1044/2020_AJSLP-20-00007

First Page

1833

Last Page

1849

Abstract

Purpose: Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches as well as complementary, state-of-the-art procedures that may improve diagnostic precision.
Method: We describe the diagnostic evaluation of a 49-yearold woman with complaints of progressive word-finding difficulty. She completed standard neurological, neuropsychological, and speech-language evaluations, as well as magnetic resonance and positron emission tomography imaging of her brain. In addition, a history of developmental speech, language, and learning abilities was obtained, as well as genetic testing and assessment of cerebrospinal fluid biomarkers. We discuss the evaluation results in the context of the most current research related to PPA diagnosis.
Conclusion: Detailed behavioral assessment, thorough intake of symptom history and neurodevelopmental differences, multimodal neuroimaging, and comprehensive examination of genes and biomarkers are of paramount importance for detecting and characterizing PPA, with ramifications for early behavioral and/or pharmacological intervention.

Funding Number

P01AG019724

Funding Sponsor

National Institute on Aging

Department

Communicative Disorders and Sciences

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