The effects of immunomodulatory activity of two types of carboxymethyl pachymaran (CMP-1 and CMP-2) on cyclophosphamide (CTX)-induced mice were investigated. Both CMP-1 and CMP-2 were found to restore the splenomegaly and alleviate the spleen lesions and the mRNA ex-pressions of TLR4, MyD88, p65 and NF-κB in spleen were also increased. CMP-1 and CMP-2 could enhance the immunity by increasing the levels of TNF-α, IL-2, IL-6, IFN-γ, Ig-A and Ig-G in serum. In addition, CMP-1 could increase the relative abundance of Bacteroidetes and reduce the relative richness of Firmicutes at the phylum level. CMP-1 and CMP-2 could reduce the relative abundance Erysipelatoclostridum at the genus level. CMP-1 and CMP-2 might enhance the immune function of immunosuppression mice by regulating the gene expression in the TLR4/NF-κB signaling pathway and changing the composition and abundance of the intestinal microbiota. The results suggested that CMP-1 and CMP-2 would be as potential immunomodulatory agents in functional foods.
National Key Research and Development Program of China
Carboxymethyl pachymaran, Cyclophosphamide, Gut microbiota, Immunomodulatory, Poria cocos
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Nutrition, Food Science and Packaging
Feng Liu, Lijia Zhang, Xi Feng, Salam A. Ibrahim, Wen Huang, and Ying Liu. "Immunomodulatory activity of carboxymethyl pachymaran on immunosuppressed mice induced by cyclophosphamide" Molecules (2021). https://doi.org/10.3390/molecules26195733