Sleep is required to consolidate odor memory and remodel olfactory synapses

Authors

• Rashmi Chandra, University of California, San Francisco
• Fatima Farah, San Jose State University
• Fernando Muñoz-Lobato, University of California, San Francisco
• Anirudh Bokka, San Jose State University
• Kelli L. Benedetti, University of California, San Francisco
• Chantal Brueggemann, University of California, San Francisco
• Mashel Fatema A. Saifuddin, University of California, San Francisco
• Julia M. Miller, University of California, San Francisco
• Joy Li, San Jose State University
• Eric Chang, San Jose State University
• Aruna Varshney, San Jose State University
• Vanessa Jimenez, San Jose State UniversityFollow
• Anjana Baradwaj, San Jose State University
• Cibelle Nassif, San Jose State University
• Sara Alladin, San Jose State University
• Kristine Andersen, San Jose State University
• Angel J. Garcia, University of California, San Francisco
• Veronica Bi, San Jose State University
• Sarah K. Nordquist, University of California, San Francisco
• Raymond L. Dunn, University of California, San Francisco
• Vanessa Garcia, San Jose State UniversityFollow
• Kateryna Tokalenko, San Jose State UniversityFollow
• Emily Soohoo, San Jose State UniversityFollow
• Fabiola Briseno, San Jose State UniversityFollow
• Sukhdeep Kaur, San Jose State UniversityFollow
• Malcolm Harris, San Jose State University
• Hazel Guillen, San Jose State University
• Decklin Byrd, San Jose State University
• Brandon Fung, San Jose State University
• Andrew E. Bykov, San Jose State University
• Emma Odisho, San Jose State UniversityFollow
• Bryan Tsujimoto, San Jose State University
• Alan Tran, San Jose State University
• Alex Duong, San Jose State University
• Kevin C. Daigle, University of California, San Francisco
• Rebekka Paisner, University of California, San Francisco
• Carlos E. Zuazo, University of California, San Francisco
• Christine Lin, University of California, San Francisco
• Aarati Asundi, University of California, San Francisco
• Matthew A. Churgin, University of Pennsylvania
• Christopher Fang-Yen, University of Pennsylvania
• Martina Bremer, San Jose State UniversityFollow
• Saul Kato, University of California, San Francisco
• Miri VanHoven, San Jose State UniversityFollow
• Noëlle D. L’Étoile, University of California, San Francisco

Publication Date

6-2-2023

Document Type

Article

Publication Title

Cell

Volume

186

DOI

10.1016/j.cell.2023.05.006

Abstract

Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear if, in any system, sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior. C. elegans neurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures.

Keywords

sleep, memory, memory consolidation, C. elegans, synapse, circuit, single cell, behavior, systems consolidation, plasticity

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Biological Sciences; Mathematics and Statistics

Recommended Citation

Rashmi Chandra, Fatima Farah, Fernando Muñoz-Lobato, Anirudh Bokka, Kelli L. Benedetti, Chantal Brueggemann, Mashel Fatema A. Saifuddin, Julia M. Miller, Joy Li, Eric Chang, Aruna Varshney, Vanessa Jimenez, Anjana Baradwaj, Cibelle Nassif, Sara Alladin, Kristine Andersen, Angel J. Garcia, Veronica Bi, Sarah K. Nordquist, Raymond L. Dunn, Vanessa Garcia, Kateryna Tokalenko, Emily Soohoo, Fabiola Briseno, Sukhdeep Kaur, Malcolm Harris, Hazel Guillen, Decklin Byrd, Brandon Fung, Andrew E. Bykov, Emma Odisho, Bryan Tsujimoto, Alan Tran, Alex Duong, Kevin C. Daigle, Rebekka Paisner, Carlos E. Zuazo, Christine Lin, Aarati Asundi, Matthew A. Churgin, Christopher Fang-Yen, Martina Bremer, Saul Kato, Miri VanHoven, and Noëlle D. L’Étoile. "Sleep is required to consolidate odor memory and remodel olfactory synapses" Cell (2023). https://doi.org/10.1016/j.cell.2023.05.006