Rashmi Chandra, University of California, San Francisco
Fatima Farah, San Jose State University
Fernando Muñoz-Lobato, University of California, San Francisco
Anirudh Bokka, San Jose State University
Kelli L. Benedetti, University of California, San Francisco
Chantal Brueggemann, University of California, San Francisco
Mashel Fatema A. Saifuddin, University of California, San Francisco
Julia M. Miller, University of California, San Francisco
Joy Li, San Jose State University
Eric Chang, San Jose State University
Aruna Varshney, San Jose State University
Vanessa Jimenez, San Jose State UniversityFollow
Anjana Baradwaj, San Jose State University
Cibelle Nassif, San Jose State University
Sara Alladin, San Jose State University
Kristine Andersen, San Jose State University
Angel J. Garcia, University of California, San Francisco
Veronica Bi, San Jose State University
Sarah K. Nordquist, University of California, San Francisco
Raymond L. Dunn, University of California, San Francisco
Vanessa Garcia, San Jose State UniversityFollow
Kateryna Tokalenko, San Jose State UniversityFollow
Emily Soohoo, San Jose State UniversityFollow
Fabiola Briseno, San Jose State UniversityFollow
Sukhdeep Kaur, San Jose State UniversityFollow
Malcolm Harris, San Jose State University
Hazel Guillen, San Jose State University
Decklin Byrd, San Jose State University
Brandon Fung, San Jose State University
Andrew E. Bykov, San Jose State University
Emma Odisho, San Jose State UniversityFollow
Bryan Tsujimoto, San Jose State University
Alan Tran, San Jose State University
Alex Duong, San Jose State University
Kevin C. Daigle, University of California, San Francisco
Rebekka Paisner, University of California, San Francisco
Carlos E. Zuazo, University of California, San Francisco
Christine Lin, University of California, San Francisco
Aarati Asundi, University of California, San Francisco
Matthew A. Churgin, University of Pennsylvania
Christopher Fang-Yen, University of Pennsylvania
Martina Bremer, San Jose State UniversityFollow
Saul Kato, University of California, San Francisco
Miri VanHoven, San Jose State UniversityFollow
Noëlle D. L’Étoile, University of California, San Francisco

Publication Date

6-2-2023

Document Type

Article

Publication Title

Cell

Volume

186

DOI

10.1016/j.cell.2023.05.006

Abstract

Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear if, in any system, sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior. C. elegans neurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures.

Keywords

sleep, memory, memory consolidation, C. elegans, synapse, circuit, single cell, behavior, systems consolidation, plasticity

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Biological Sciences; Mathematics and Statistics

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