Network anatomy in logopenic variant of primary progressive aphasia

Authors

Maria Luisa Mandelli, University of California, San Francisco
Diego L. Lorca-Puls, University of California, San Francisco
Sladjana Lukic, University of California, San Francisco
Maxime Montembeault, University of California, San Francisco
Andrea Gajardo-Vidal, University of California, San Francisco
Abigail Licata, University of California, San Francisco
Aaron Scheffler, University of California, San Francisco
Giovanni Battistella, University of California, San Francisco
Stephanie M. Grasso, The University of Texas at Austin
Rian Bogley, University of California, San Francisco
Buddhika M. Ratnasiri, University of California, San Francisco
Renaud La Joie, University of California, San Francisco
Nidhi S. Mundada, University of California, San Francisco
Eduardo Europa, San Jose State UniversityFollow
Gil Rabinovici, University of California, San Francisco
Bruce L. Miller, University of California, San Francisco
Jessica De Leon, University of California, San Francisco
Maya L. Henry, The University of Texas at Austin
Zachary Miller, University of California, San Francisco
Maria Luisa Gorno-Tempini, University of California, San Francisco

Publication Date

1-1-2023

Document Type

Article

Publication Title

Human Brain Mapping

DOI

10.1002/hbm.26388

Abstract

The logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss of repetition and naming skills resulting from left posterior temporal and inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted by the disease (epicenters) and investigate whether atrophy spreads through predetermined networks. First, we used cross-sectional structural MRI data from individuals with lvPPA to define putative disease epicenters using a surface-based approach paired with an anatomically fine-grained parcellation of the cortical surface (i.e., HCP-MMP1.0 atlas). Second, we combined cross-sectional functional MRI data from healthy controls and longitudinal structural MRI data from individuals with lvPPA to derive the epicenter-seeded resting-state networks most relevant to lvPPA symptomatology and ascertain whether functional connectivity in these networks predicts longitudinal atrophy spread in lvPPA. Our results show that two partially distinct brain networks anchored to the left anterior angular and posterior superior temporal gyri epicenters were preferentially associated with sentence repetition and naming skills in lvPPA. Critically, the strength of connectivity within these two networks in the neurologically-intact brain significantly predicted longitudinal atrophy progression in lvPPA. Taken together, our findings indicate that atrophy progression in lvPPA, starting from inferior parietal and temporoparietal junction regions, predominantly follows at least two partially nonoverlapping pathways, which may influence the heterogeneity in clinical presentation and prognosis.

Funding Number

03–75271 DHS/ADP/ARCC

Funding Sponsor

National Institutes of Health

Keywords

Alzheimer's disease, cortical atrophy, intrinsic connectivity networks, logopenic variant, longitudinal study, primary progressive aphasia

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Department

Communicative Disorders and Sciences

Recommended Citation

Maria Luisa Mandelli, Diego L. Lorca-Puls, Sladjana Lukic, Maxime Montembeault, Andrea Gajardo-Vidal, Abigail Licata, Aaron Scheffler, Giovanni Battistella, Stephanie M. Grasso, Rian Bogley, Buddhika M. Ratnasiri, Renaud La Joie, Nidhi S. Mundada, Eduardo Europa, Gil Rabinovici, Bruce L. Miller, Jessica De Leon, Maya L. Henry, Zachary Miller, and Maria Luisa Gorno-Tempini. "Network anatomy in logopenic variant of primary progressive aphasia" Human Brain Mapping (2023). https://doi.org/10.1002/hbm.26388