Evaluating novel silica hydride‐based stationary phases for the analysis of phytocannabinoids and other psychoactive drugs

Publication Date

June 2019

Document Type

Article

Publication Title

Journal of Separation Science

Volume

42

Issue

11

DOI

10.1002/jssc.201900013

First Page

1972

Last Page

1979

Abstract

Three silica hydride based novel chromatographic phases chemically‐bonded with allyloxy‐DL‐alpha‐tocopherol, allylpentafluorophenyl, and 1‐eicosene moieties were evaluated as separation media for selected phytocannabinoids and other substances of abuse. In order to assess column selectivity, a series of reference standards was analyzed and detected by using liquid chromatography with mass spectrometry. Further, quantitative detections of cannabidiol and tetrahydrocannabinol were attempted for the extracts of cannabis plants and cannabidiol gummy formulation. For potential bioanalytical applications, the columns were evaluated for substance screening in a human urine matrix. In summary, the newly developed columns are functional and effective for the analysis of phytocannabinoids and various psychoactive drugs with or without the presence of biological matrices.

Keywords

controlled substances, drug analysis, hydride stationary phases, liquid chromatography‐mass spectrometry, phytocannabinoids

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