Selective Light-Driven Chemoenzymatic Trifluoromethylation/Hydroxylation of Substituted Arenes
Publication Date
March 2018
Document Type
Article
Publication Title
ACS Catalysis
Volume
8
Issue
3
DOI
10.1021/acscatal.7b04160
First Page
2225
Last Page
2229
Abstract
The merging of photoredox trifluoromethylation with hybrid P450 BM3 variants has enabled the selective light-driven functionalization of several arenes. This approach capitalizes on the unique photochemical properties of the Ru(II)-diimine photosensitizer to initiate single electron transfer events. Under photoredox conditions, a CF3 radical promoted by the d6 metal complex can add to arenes. In the hybrid P450 BM3 enzymes, the covalently attached Ru(II)-diimine photosensitizer provides the necessary electrons to perform, upon visible light activation, P450 oxyfunctionalizations on the trifluoromethylated substrates.
Keywords
chemoenzymatic process, electron transfer, light-driven biocatalysis, Ru(II)-diimine photosensitizer, trifluoromethylation/hydroxylation
Recommended Citation
Victor Sosa, Marya Melkie, Carolina Sulca, Jennifer Li, Lawrence Tang, Jeffrey Li, Justin Faris, Bridget Foley, Tam Banh, Mallory Kato, and Lionel Cheruzel. "Selective Light-Driven Chemoenzymatic Trifluoromethylation/Hydroxylation of Substituted Arenes" ACS Catalysis (2018): 2225-2229. https://doi.org/10.1021/acscatal.7b04160
Comments
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