Publication Date
11-1-2023
Document Type
Article
Publication Title
Nutrients
Volume
15
Issue
21
DOI
10.3390/nu15214527
Abstract
Carboxymethyl pachymaran (CMP) was treated via high-temperature and cellulase hydrolysis to obtain HTCMP, HTEC-24, and HTEC-48. The chemical structure and in vivo antitumor activities of the four types of CMPs were investigated. Compared with CMP (787.9 kDa), the molecular weights of HTCMP, HTEC-24, and HTEC-48 were decreased to 429.8, 129.9, and 68.6 kDa, respectively. The viscosities and particle sizes of the CMPs could also decrease with the decline in the molecular weights. All the CMPs showed antitumor abilities, but HTEC-24 exhibited the best activity. In the animal study, when curing the spleen and thymus, CMPs displayed immunomodulatory effects by increasing the secretion of IFN-γ and IL2 in mice. The CMPs also exerted an antitumor ability by regulating the gut microbiota in tumor-bearing mice. Our results established a foundation to develop an antitumor drug with CMP.
Funding Number
ZY2023Q035
Funding Sponsor
Special Project of Central Government for Local Science and Technology Development of Hubei Province
Keywords
antitumor activities, carboxymethyl pachymaran, gut microbiota, molecular weight, structural characterization
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Department
Nutrition, Food Science and Packaging
Recommended Citation
Yalin Zhao, Xi Feng, Lijia Zhang, Wen Huang, and Ying Liu. "Antitumor Activity of Carboxymethyl Pachymaran with Different Molecular Weights Based on Immunomodulatory and Gut Microbiota" Nutrients (2023). https://doi.org/10.3390/nu15214527
