Publication Date
10-15-2024
Document Type
Article
Publication Title
ACS Omega
Volume
9
Issue
41
DOI
10.1021/acsomega.4c07869
First Page
42593
Last Page
42601
Abstract
Coatings with antibiofilm properties are desirable for biomedical applications. Titanium dioxide (TiO2) has been explored as an antimicrobial agent in materials development primarily due to it being an excellent photocatalyst. Candida glabrata (C. glabrata) is an emerging human fungal pathogen with known high resistance to oxidative stress. Here, we fabricated a polydimethylsiloxane/titanium dioxide (PDMS/TiO2) nanocomposite coating and tested its antibiofilm activities against C. glabrata. The resulting nanocomposite exhibited >50% reduction in C. glabrata biofilm formation with 2.5 wt % TiO2 loading, even in the dark. Through ROS detection and surface characterization, the antibiofilm activity was attributed to the synergistic interaction of TiO2 nanoparticles with the PDMS matrix, which resulted in the impediment of hydrophobic recovery. This work provides a design strategy to develop antibiofilm coatings against C. glabrata.
Funding Number
1R16AI167832
Funding Sponsor
National Institutes of Health
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Department
Chemical and Materials Engineering
Recommended Citation
Khoi Nguyen Nguyen, Leena Sao, Kevin Kyllo, Danitza Hernandez, Samantha Salomon, Kalp Shah, Dahyun Oh, and Katy C. Kao. "Antibiofilm Activity of PDMS/TiO2 against Candida glabrata through Inhibited Hydrophobic Recovery" ACS Omega (2024): 42593-42601. https://doi.org/10.1021/acsomega.4c07869
