Plasma-Water Interaction: Measuring RONS to Investigate the Plasma-Wound Interaction Process

Publication Date

1-1-2024

Document Type

Conference Proceeding

Publication Title

2024 IEEE Integrated STEM Education Conference, ISEC 2024

DOI

10.1109/ISEC61299.2024.10664850

Abstract

Non-equilibrium plasma's ability to remain at room temperature allows for its application in wound healing and sterilization, and because RONS play a pivotal role in the coordination of the standard wound-healing process, this study analyzes the impact plasma has on the concentration of various RONS (NO2-, NO3-, H2O2). NO2- and NO3- play an important role in vascular homeostasis, inflammation, and antimicrobial action while H2O2 acts as a signaling molecule that drives mechanisms needed for the dermal wound healing process. In order to determine the presence of RONS, we initially measured pH because if a solution becomes more acidic, then we can hypothesize that there are RONS present. We quantified the difference in plasma absorbance based on time intervals to determine whether it increased absorbance. To quantify the concentration of various molecular species, reference curves are being established using standard solutions (NaNO2, NaNO3, H2O2), and calibration curves will be created through a curve fitting routine which compares the reference curves to the PAW absorption curve.

Department

Mechanical Engineering

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