Document Type

Article

Publication Date

January 1991

Publication Title

Biophysical Journal

First Page

235

Last Page

245

Disciplines

Astrophysics and Astronomy

Abstract

Rate processes in proteins are often not adequately described by simple exponential kinetics. Instead of modeling the kinetics in the time domain, it can be advantageous to perform a numerical inversion leading to a rate distribution function f(lambda). The features observed in f(lambda) (number, positions, and shapes of peaks) can then be interpreted. We discuss different numerical techniques for obtaining rate distribution functions, with special emphasis on the maximum entropy method. Examples are given for the application of these techniques to flash photolysis data of heme proteins.

Comments

© 2007 Biophysical Society Doi:10.1016/S0006-3495(92)81830-1

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