Document Type
Article
Publication Date
January 1991
Publication Title
Biophysical Journal
First Page
235
Last Page
245
Disciplines
Astrophysics and Astronomy
Abstract
Rate processes in proteins are often not adequately described by simple exponential kinetics. Instead of modeling the kinetics in the time domain, it can be advantageous to perform a numerical inversion leading to a rate distribution function f(lambda). The features observed in f(lambda) (number, positions, and shapes of peaks) can then be interpreted. We discuss different numerical techniques for obtaining rate distribution functions, with special emphasis on the maximum entropy method. Examples are given for the application of these techniques to flash photolysis data of heme proteins.
Recommended Citation
Todd B. Sauke, P. J. Steinback, K. Chu, H. Frauenfelder, J. B. Johnson, D. C. Lamb, G. U. Nienhaus, and R. D. Young. "Determination of rate distributions from kinetic experiments" Biophysical Journal (1991): 235-245.
Comments
© 2007 Biophysical Society Doi:10.1016/S0006-3495(92)81830-1