Document Type
Article
Publication Date
April 2014
Publication Title
Pediatric Blood and Cancer
Volume
61
Issue Number
4
First Page
601
Last Page
605
DOI
10.1002/pbc.24830
ISSN
1545-5017
Disciplines
Communication Sciences and Disorders | Speech and Hearing Science | Speech Pathology and Audiology
Abstract
BackgroundReporting ototoxicity is frequently complicated by use of various ototoxicity criteria. The International Society of Pediatric Oncology (SIOP) ototoxicity grading scale was recently proposed for standardized use in reporting hearing loss outcomes across institutions. The aim of this study was to evaluate the concordance between the Chang and SIOP ototoxicity grading scales. Differences between the two scales were identified and the implications these differences may have in the clinical setting were discussed.ProceduresAudiological evaluations were reviewed for 379 patients with newly diagnosed medulloblastoma (ages 3–21 years). Each patient was enrolled on one of two St. Jude clinical protocols that included craniospinal radiation therapy and four courses of 75 mg/m2 cisplatin chemotherapy. The latest audiogram conducted 5.5–24.5 months post-protocol treatment initiation was graded using the Chang and SIOP ototoxicity criteria. Clinically significant hearing loss was defined as Chang grade ≥2a and SIOP ≥2. Hearing loss was considered serious (requiring a hearing aid) at the level of Chang grade ≥2b and SIOP ≥3.ResultsA strong concordance was observed between the Chang and SIOP ototoxicity scales (Stuart's tau-c statistic = 0.89, 95% CI: 0.86, 0.91). Among those patients diagnosed with serious hearing loss, the two scales were in good agreement. However, the scales deviated from one another in classifying patients with less serious or no hearing loss.ConclusionsAlthough discrepancies between the Chang and SIOP ototoxicity scales exist primarily for patients with no or minimal hearing loss, the scales share a strong concordance overall. Pediatr Blood Cancer 2014;61:601–605. © 2013 Wiley Periodicals, Inc.
Recommended Citation
Johnnie Bass, Jie Huang, Arzu Onar-Thomas, Kay Chang, Shaum Bhagat, Murali Chintagumpala, Ute Bartels, Sridharan Gururangan, Tim Hassall, John Heath, Geoffrey McCowage, Richard Cohn, Michael Fisher, Giles Robinson, Alberto Broniscer, Amar Gajjar, and James Gurney. "Concordance between the Chang and the International Society of Pediatric Oncology (SIOP) ototoxicity grading scales in patients treated with cisplatin for medulloblastoma" Pediatric Blood and Cancer (2014): 601-605. https://doi.org/10.1002/pbc.24830
Comments
This is the Accepted Manuscript of an article that appeared in Pediatric Blood and Cancer, volume 61, issue 4, 2014. The Version of Record is available at http://dx.doi.org/10.1002/pbc.24830