Publication Date

Summer 2021

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry

Advisor

LIonel Cheruzel

Keywords

Aqueous Catalysis, Aqueous Chemistry, Biological catalyst, Chemoenzymatic reaction

Subject Areas

Organic chemistry; Medicine; Biochemistry

Abstract

Synthesis of small molecules for medicine, agriculture, or research often requires the formation of carbon-carbon and carbon-heteroatoms bonds, and palladium catalyzed reactions have emerged as a potent technique for these cross-coupling reactions. To address increasing catalysts demands, our research has focused on the development of a versatile catalyst platform bearing imidazole pendants as ligands to support cross-coupling reactions under mild conditions, an area of current interest. A series of bridged imidazole ligands was synthesized using a modular approach and characterized by 1H NMR spectroscopy. The catalytic activity of the complexes was measured for cross-coupling reactions in aerobic conditions, over a range of temperatures. The bidentate ligand platform can be tuned by varying the steric bulk and electronic environment of the compounds. Additionally, functionalities can be installed to provide a handle for special applications including tethering complexes to solid support or biomolecules. The imidazole ligand framework shows promise for cross-coupling reactions even under mild conditions.

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