Publication Date

Summer 2021

Degree Type


Degree Name

Master of Science (MS)




LIonel Cheruzel


Aqueous Catalysis, Aqueous Chemistry, Biological catalyst, Chemoenzymatic reaction

Subject Areas

Organic chemistry; Medicine; Biochemistry


Synthesis of small molecules for medicine, agriculture, or research often requires the formation of carbon-carbon and carbon-heteroatoms bonds, and palladium catalyzed reactions have emerged as a potent technique for these cross-coupling reactions. To address increasing catalysts demands, our research has focused on the development of a versatile catalyst platform bearing imidazole pendants as ligands to support cross-coupling reactions under mild conditions, an area of current interest. A series of bridged imidazole ligands was synthesized using a modular approach and characterized by 1H NMR spectroscopy. The catalytic activity of the complexes was measured for cross-coupling reactions in aerobic conditions, over a range of temperatures. The bidentate ligand platform can be tuned by varying the steric bulk and electronic environment of the compounds. Additionally, functionalities can be installed to provide a handle for special applications including tethering complexes to solid support or biomolecules. The imidazole ligand framework shows promise for cross-coupling reactions even under mild conditions.