Reduced haemodynamic coupling and exercise are associated with vascular stiffening in pulmonary arterial hypertension

Authors

Alessandro Bellofiore, San Jose State University
Eric Dinges, University of Wisconsin-Madison
Robert Naeije, Erasme University Hospital
Hamorabi Mkrdichian, Feinberg School of Medicine
Lauren Beussink-Nelson, Feinberg School of Medicine
Melissa Bailey, University of Wisconsin-Madison
Michael Cuttica, Northwestern University
Ranya Sweis, Feinberg School of Medicine
James Runo, University of Wisconsin-Madison
Jon Keevil, University of Wisconsin-Madison
Christopher Francois, University of Wisconsin-Madison
Sanjiv Shah, Northwestern University
Naomi Chesler, University of Wisconsin-Madison

Document Type

Article

Publication Date

January 2016

Publication Title

Heart

Volume

103

Issue Number

6

First Page

421

Last Page

427

DOI

10.1136/heartjnl-2016-309906

Disciplines

Biomedical | Biomedical Engineering and Bioengineering

Abstract

Inadequate right ventricular (RV) and pulmonary arterial (PA) functional responses to exercise are important yet poorly understood features of pulmonary arterial hypertension (PAH). This study combined invasive catheterisation with echocardiography to assess RV afterload, RV function and ventricular–vascular coupling in subjects with PAH.

Comments

This is the Accepted Manuscript of an article that appeared in Heart, volume 103, issue 6, 2016. The Version of Record (VOR) may be found at http://dx.doi.org/10.1136/heartjnl-2016-309906

Recommended Citation

Alessandro Bellofiore, Eric Dinges, Robert Naeije, Hamorabi Mkrdichian, Lauren Beussink-Nelson, Melissa Bailey, Michael Cuttica, Ranya Sweis, James Runo, Jon Keevil, Christopher Francois, Sanjiv Shah, and Naomi Chesler. "Reduced haemodynamic coupling and exercise are associated with vascular stiffening in pulmonary arterial hypertension" Heart (2016): 421-427. https://doi.org/10.1136/heartjnl-2016-309906